Endocrine Abstracts

Objectives: Vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-1) are key regulators in human ovarian angiogenesis. VEGF promotes blood vessel growth while sVEGFR-1 is a VEGF antagonist. A promising candidate in sVEGFR-1 regulation is TIMP-1 (tissue inhibitor of metalloproteinases 1), which is involved in extracellular matrix remodelling. The aim of our research is to determine if TIMP-1 influences sVEGFR-1 secretion in endothelial cells.<p class="a...

Objectives: It is well known that compounds of follicular fluid, which is rich in carbohydrates, are able to regulate the expression of angiogenesis-related genes in endothelial cells. Nuclear factor κ B (NF-κB) transcription factors are important candidates in modulating the expression of these genes. The aim of our research is to determine if NF-κB factors are maybe involved in the regulation of endothelial angiogenesis-related genes and thus in ovarian angiog...